Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

Author(s):Show less -

Farah, Daniela ; Nunes, Jonas ; Sartori, Michelle ; Dias, Danielle da Silva ; Sirvente, Raquel ; Silva, Maikon B. ; Fiorino, Patricia ; Morris, Mariana ; Llesuy, Susana ; Farah, Vera ; Irigoyen, Maria-Claudia ; De Angelis, Katia

• Document type: Journal article
• Source: PLoS One; v. 11, n. 12 DEC 8 2016.
• Web of Science Citations: 8

Abstract

The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group):Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42 +/- 0.04 vs. SC:0.24 +/- 0.05) and in arterial pressure (SF:122 +/- 3 vs. SC:113 +/- 1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidationSF: 3.30 +/- 0.09 vs. SC:1.45 +/- 0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)SF: 2.5 +/- 0.5 vs. SC:12.7 +/- 1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35 +/- 0.04), arterial pressure (118 +/- 2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training. (AU)

• FAPESP's process: 12/01873-5 - Effects of aerobic exercise in cardiometabolic dysfunctions induced by high fructose intake since weaning in rats
• Grantee: Daniela de Moura Azevedo Tuma Farah
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants