Connexins and their channels in inflammation

Autor(es)

Willebrords, Joost ; Yanguas, Sara Crespo ; Maes, Michael ; Decrock, Elke ; Wang, Nan ; Leybaert, Luc ; Kwak, Brenda R. ; Green, Colin R. ; Cogliati, Bruno ; Vinken, Mathieu

• Tipo de documento: Artigo de Revisão
• Fonte: CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY; v. 51, n. 6, p. 413-439, NOV-DEC 2016.
• Citações Web of Science: 23

Resumo

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration. Despite the wealth of knowledge regarding the involvement of cellular communication in inflammation, studies on the role of connexin-based channels in this process have only begun to emerge in the last few years. In this paper, a state-of-the-art overview of the effects of inflammation on connexin signaling is provided. Vice versa, the involvement of connexins and their channels in inflammation will be discussed by relying on studies that use a variety of experimental tools, such as genetically modified animals, small interfering RNA and connexin-based channel blockers. A better understanding of the importance of connexin signaling in inflammation may open up towards clinical perspectives. (AU)

• Processo FAPESP: 13/50420-6 - Canais de conexina e panexina como alvos terapêuticos e biomarcadores nas doenças hepáticas aguda e crônica
• Beneficiário: Mathieu Frederick Alexander Vinken
• Modalidade de apoio: Auxílio à Pesquisa - Programa SPEC