Correlation between the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 and the European Consensus Lupus Activity Measurement in juvenile systemic lupus erythematosus

Autor(es)

Sato, J. O. ; Corrente, J. E. ; Saad-Magalhaes, C.

• Tipo de documento: Artigo Científico
• Fonte: Lupus; v. 25, n. 13, p. 1479-1484, NOV 2016.
• Citações Web of Science: 0

Resumo

Objective The objective of this study was to assess Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and European Consensus Lupus Activity Measurement (ECLAM) disease activity correlation in addition to their respective correlation to Pediatric Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (Ped-SDI), in juvenile systemic lupus erythematosus (JSLE). Methods The activity indices were scored retrospectively and summarized by adjusted means during follow-up. The Ped-SDI was scored during the last visit for those with more than six months follow-up. Pearson correlation between the Modified SLEDAI-2K and ECLAM, as well as Spearman correlations between the Modified SLEDAI-2K, ECLAM, and Ped-SDI were calculated. The receiver operating characteristic (ROC) curve was calculated for both activity indices discriminating damage measured by Ped-SDI. Results Thirty-seven patients with mean age at diagnosis 112.9 years and mean follow-up time 3.2 +/- 2.4 years were studied. The Modified SLEDAI-2K and ECLAM adjusted means were highly correlated (r=0.78, p<0.001). Similarly, Spearman correlation between the activity indices was also high (r(s)>0.7, p<0.001), but Modified SLEDAI-2K and ECLAM correlation with Ped-SDI was only moderate. ROC analysis discriminant performance for both activity indices resulted in area under curve (AUC) of 0.74 and 0.73 for Modified SLEDAI-2K and ECLAM, respectively. Conclusion The high correlation found between the Modified SLEDAI-2K and ECLAM adjusted means indicated that both tools can be equally useful for longitudinal estimates of JSLE activity. (AU)

• Processo FAPESP: 14/07659-0 - European League Against Rheumatism (EULAR)
• Beneficiário: Juliana de Oliveira Sato
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior