Early dengue virus interactions: the role of dendritic cells during infection

Autor(es)

Santos Souza, Higo Fernando ; Almeida, Bianca da Silva ; Boscardin, Silvia Beatriz

• Tipo de documento: Artigo de Revisão
• Fonte: VIRUS RESEARCH; v. 223, p. 88-98, SEP 2 2016.
• Citações Web of Science: 5

Resumo

Dengue is an acute infectious disease caused by dengue virus (DENV) that affects approximately 400 million people annually, being the most prevalent human arthropod-borne disease. DENV infection causes a wide variety of clinical manifestations that range from asymptomatic to dengue fever, and in some cases may evolve to the more severe dengue hemorrhagic fever and dengue shock syndrome. The exact reasons why some patients do not have symptoms while others develop the severe forms of disease are still elusive, but gathered evidence showed correlation between a secondary infection with a heterologous DENV serotype and the occurrence of severe symptoms. Despite several advances, the mechanisms of DENV infection are still not completely elucidated, and efforts have been made to understand the development of immunity and/or pathology to DENV. When a mosquito transmits DENV, the virus is initially deposited in the skin, where mononuclear phagocytic cells, such as dendritic cells (DCs), become infected. DCs play a critical role in the induction of immune responses, as they are able to rapidly detect pathogen associated molecular patterns, endocytose and process antigens, and efficiently activate naive-T and B cells. Recent findings have shown that DCs serve as DENV targets, but they are also important mediators of immunity against the virus. In this review, we will briefly discuss DENV infection pathogenesis, and introduce DCs as central players in the induction of anti-DENV immune responses. Then, we will review in more detail how DENV interacts with and is sensed by DCs, with particular emphasis in two classes of receptors implicated in viral entry. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/11442-4 - Estudo dos mecanismos protetores induzidos pela vacinação de camundongos com anticorpos de fusão capazes de direcionar proteínas do vírus da dengue para células dendríticas
• Beneficiário: Silvia Beatriz Boscardin
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50631-0 - Imagem e aperfeiçoamento da proteção imunológica contra parasitas da malária
• Beneficiário: Silvia Beatriz Boscardin
• Modalidade de apoio: Auxílio à Pesquisa - Regular