Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

HIV-1 Nef: Taking Control of Protein Trafficking

Texto completo
Autor(es):
Pereira, Estela A. ; daSilva, Luis L. P.
Número total de Autores: 2
Tipo de documento: Artigo de Revisão
Fonte: TRAFFIC; v. 17, n. 9, p. 976-996, SEP 2016.
Citações Web of Science: 26
Resumo

The Nef protein of the human immunodeficiency virus is a crucial determinant of viral pathogenesis and disease progression. Nef is abundantly expressed early in infection and is thought to optimize the cellular environment for viral replication. Nef controls expression levels of various cell surface molecules that play important roles in immunity and virus life cycle, by directly interfering with the itinerary of these proteins within the endocytic and late secretory pathways. To exert these functions, Nef physically interacts with host proteins that regulate protein trafficking. In recent years, considerable progress was made in identifying host-cell-interacting partners for Nef, and the molecular machinery used by Nef to interfere with protein trafficking has started to be unraveled. Here, we briefly review the knowledge gained and discuss new findings regarding the mechanisms by which Nef modifies the intracellular trafficking pathways to prevent antigen presentation, facilitate viral particle release and enhance the infectivity of HIV-1 virions. (AU)

Processo FAPESP: 14/02438-6 - Estudos com Bunyaviridae causadores de doença
Beneficiário:Luiz Tadeu Moraes Figueiredo
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/25812-0 - Estudo sobre as interações moleculares de HIV-1 com o sistema de endomembranas da célula hospedeira
Beneficiário:Luis Lamberti Pinto da Silva
Linha de fomento: Auxílio à Pesquisa - Regular