Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates

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Shaw-Saliba, Kathryn ; Clarke, David ; Santos, Jorge M. ; Menezes, Maria Jose ; Lim, Caeul ; Mascarenhas, Anjali ; Chery, Laura ; Gomes, Edwin ; March, Sandra ; Bhatia, Sangeeta N. ; Rathod, Pradipsinh K. ; Ferreira, Marcelo U. ; Catteruccia, Flaminia ; Duraisingh, Manoj T.

• Tipo de documento: Artigo Científico
• Fonte: International Journal for Parasitology; v. 46, n. 11, p. 679-683, OCT 2016.
• Citações Web of Science: 5

Resumo

Plasmodium vivax is the most geographically widespread malaria parasite. Unique features of transmission biology complicate P. vivax control. Interventions targeting transmission are required for malaria eradication. In the absence of an in vitro culture, transmission studies rely on live isolates from non-human primates or endemic regions. Here, we demonstrate P. vivax gametocytes from both India and Brazil are stable during cryopreservation. Importantly, cryopreserved gametocytes from Brazil were capable of infecting three anopheline mosquito species in feedings done in the United States. These findings create new opportunities for transmission studies in diverse locales. (C) 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/52729-9 - Determinantes e consequências das infecções assintomáticas por plasmódios: estudos de base populacional na Amazônia rural brasileira
• Beneficiário: Marcelo Urbano Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular