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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

P2Y(2) purinergic receptors are highly expressed in cardiac and diaphragm muscles of mdx mice, and their expression is decreased by suramin

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Autor(es):
Moreira, Drielen De Oliveira ; Neto, Humberto Santo ; Marques, Maria Julia
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: MUSCLE & NERVE; v. 55, n. 1, p. 116-121, JAN 2017.
Citações Web of Science: 3
Resumo

Introduction: In Duchenne muscular dystrophy (DMD) and in the mdx mouse model of DMD, the lack of dystrophin leads to increased calcium influx and muscle necrosis. Patients suffer progressive muscle loss, and cardiomyopathy is an important determinant of morbidity. P2 purinergic receptors participate in the increased calcium levels in dystrophic skeletal muscles. Methods: In this study, we evaluated whether P2 receptors are involved in cardiomyopathy in mdx mice at later stages of the disease. Results: Western blotting revealed that P2Y(2) receptor levels were upregulated (54%) in dystrophic heart compared with a normal heart. Suramin reduced the levels of P2Y(2) to almost normal values. Suramin also decreased heart necrosis (reduced CK-MB) and the expression of the stretch-activated calcium channel TRPC1. Conclusions: This study suggests that P2Y(2) may participate in cardiomyopathy in mdx mice. P2-selective drugs with specific actions in the dystrophic heart may ameliorate cardiomyopathy in dystrophinopathies. Muscle Nerve55: 116-121, 2017 (AU)

Processo FAPESP: 11/51697-6 - Mecanismos de ação do ácido eicosapentanóico (EPA) na proteção a mionecrose em fibras musculares distróficas
Beneficiário:Maria Julia Marques
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/03498-7 - Mecanismos de ação da suramina na cardiomiopatia do camundongo mdx
Beneficiário:Drielen de Oliveira Moreira
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/04782-6 - Estudos pré-clínicos no camundongo mdx: metabolômica, biomarcadores e terapia com ômega-3
Beneficiário:Maria Julia Marques
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica
Beneficiário:Maria Julia Marques
Linha de fomento: Auxílio à Pesquisa - Regular