| Texto completo | |
| Autor(es): |
de Oliveira, Amanda R.
;
Reimer, Adriano E.
;
Reis, Fernando M. C. V.
;
Brandao, Marcus L.
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Experimental Brain Research; v. 235, n. 2, p. 429-436, FEB 2017. |
| Citações Web of Science: | 6 |
| Resumo | |
Considering the complexity of aversive information processing and defensive response expression, a combined action of stress modulators may be required for an optimal performance during threatening situations. Dopamine is now recognized as one of the most active modulators underlying states of fear and anxiety. On the other hand, activation of hypothalamic-pituitary-adrenocortical (HPA) axis, which leads to the release of corticosterone in rodents, has been considered a key part of the stress response. The current study is an extension of prior work investigating modulatory effects of dopamine and corticosterone on conditioned fear expression. We have showed that corticosterone, acting through mineralocorticoid receptors in the ventral tegmental area (VTA), upregulates dopaminergic system in the basolateral amygdala (BLA), enabling the expression of conditioned freezing response. The novel question addressed here is whether VTA-BLA dopaminergic signaling is necessary for increases in corticosterone during conditioned fear expression. Using site-specific treatment with D-2-like agonist quinpirole (VTA) and D-2-like antagonist sulpiride (BLA), we evaluated freezing and plasma corticosterone in rats exposed to a light used as aversive conditioned stimulus (CS). Intra-VTA quinpirole and intra-BLA sulpiride significantly decreased freezing expression in the conditioned fear test, but this anxiolytic-like effect of the dopaminergic drugs was not associated with changes in plasma corticosterone concentrations. Altogether, data suggest that interferences with the ability of the CS to activate the dopaminergic VTA-BLA pathway reduce the expression of freezing, but activation of the HPA axis seems to occur upstream of the recruitment of dopaminergic mechanisms in conditioned fear states. (AU) | |
| Processo FAPESP: | 16/04620-1 - Dopamina e neurocininas na mediação da interface sensório-motora do medo e da ansiedade |
| Beneficiário: | Marcus Lira Brandão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/04741-5 - Análise da mediação da e 5-HT do filtro sensório-motor e do processamento de informações condicionadas de medo em um modelo animal de transtorno obsessivo compulsivo |
| Beneficiário: | Adriano Edgar Reimer |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 10/50669-6 - Modulacao da mediacao dopaminergica do medo e da ansiedade por fatores hormonais (eixo hipotalamo pituitaria adrenal). |
| Beneficiário: | Amanda Ribeiro de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 15/20487-7 - Extinção do medo em um modelo animal de transtorno obsessivo-compulsivo: influência de diferenças de sexo e ciclo estral |
| Beneficiário: | Adriano Edgar Reimer |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |