Collagen and tenascin-C expression along the migration pathway of mouse primordial germ cells

Autor(es)

Soto-Suazo, Mauricio ; San Martin, Sebastian ; Zorn, Telma M. T. ^[3]

• Tipo de documento: Artigo Científico
• Fonte: Histochemistry and Cell Biology; v. 121, n. 2, p. 149-153, fev. 2004.
• Área do conhecimento: Ciências Biológicas - Morfologia
• Assunto(s): Histologia Movimento celular Matriz extracelular Gametas

Resumo

Primordial germ cells (PGCs) are the progenitor cells of the vertebrate germ line. These cells originate outside of the embryo and, through separation, migration, and colonization, arrive at the genital ridge, contributing to gonad development. Diverse extracellular matrix molecules are present along the PGC migratory pathway, permitting or inhibiting PGC displacement. Collagens and tenascin form the substratum for in vitro migration of neural crest cells and PGCs. However, little is known about the expression and distribution of these molecules during in situ PGC migration. Using immunohistochemistry, we identified tenascin-C and types I, III, and V collagen along the mouse PGC migration pathway. These molecules were spatiotemporally expressed in basement membranes of hindgut, coelomic epithelia, and mesonephric tubules and mesenchyme throughout the study. Our results complement previous data from our laboratory and contribute to building comprehension of the composition of the mouse PGC migratory pathway extracellular matrix, thereby enhancing understanding of the process. (AU)

• Processo FAPESP: 00/04078-4 - Caracterizacao e distribuicao de proteoglicanos da matriz extracelular no processo de decidualizacao do endometrio em camundongos.
• Beneficiário: Sebastian Andres San Martin Henriquez
• Linha de fomento: Bolsas no Brasil - Mestrado