Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment

Autor(es)

Pereira, Tatiana Aparecida ; Ramos, Danielle Nishida ; Lopez, Renata F. V.

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 7, MAR 13 2017.
• Citações Web of Science: 8

Resumo

Low frequency ultrasound (LFU) enhances skin permeability via the formation of heterogeneous localized transport regions (LTRs). In this work, hydrogels with different zeta potentials were used as the coupling medium for LFU to investigate their contribution to LTR patterns and to the skin penetration of two model drugs, calcein and doxorubicin (DOX). When hydrogels were used, LTRs covering at least a 3-fold greater skin area were observed compared to those resulting from traditional LFU treatment and sodium lauryl sulfate. More LTRs resulted in an enhancement of calcein skin permeation. The zeta potential of the hydrogels affected the skin penetration of the positively charged DOX; the cationic coupling medium decreased the DOX recovered from the viable epidermis by 2.8-fold, whereas the anionic coupling medium increased the DOX accumulation in the stratum corneum by 4.4-fold. Therefore, LFU/hydrogel treatment increases LTRs areas and can target ionized drugs to specific skin layers depending on the zeta potential of the coupling medium. (AU)

• Processo FAPESP: 10/20794-3 - Influência do ultrassom de baixa frequência (LFU) associado a diferentes meios de acoplamento na permeabilidade da pele e no tratamento tópico do câncer de pele.
• Beneficiário: Tatiana Aparecida Pereira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/22451-7 - Sistemas de liberação sustentada e direcionada de fármacos para o tecido epitelial
• Beneficiário: Renata Fonseca Vianna Lopez
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/06202-9 - Influência do ultrassom de baixa frequência na penetração cutânea de nanopartículas lipídicas sólidas e sua potencial aplicação no tratamento do câncer de pele
• Beneficiário: Renata Fonseca Vianna Lopez
• Modalidade de apoio: Auxílio à Pesquisa - Regular