Phenolic Isomers from Plantago catharinea Leaves: Isolation, Identification, Quantification and in vitro Antioxidant Activity

Autor(es)

de Souza Mesquita, Leonardo Mendes ; da Rocha, Claudia Quintino ; Lima Affonso, Luiz Henrique ; Cerulli, Antonietta ; Piacente, Sonia ; Pereira Tangerina, Marcelo Marucci ; Goncalves Martins, Maria Bernadete ; Vilegas, Wagner

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 12, n. 3, p. 409-412, MAR 2017.
• Citações Web of Science: 1

Resumo

In this study we isolated two polyphenolic acids of m/z 639, called catharinol A and catharinol B, from Plantago catharinea L. (Plantaginaceae) leaves. Although presenting very similar structures, catharinol A showed higher antioxidant activity when compared with gallic acid and quercetin standards. These compounds are position isomers and present in their chemical structure the rare sugar D-allose. Molecules with similar constitution are known to have important biological activities such as antitumor and immunosuppressive. These compounds were isolated by high-performance liquid chromatography (HPLC) and characterized by mass spectrometry (FIA-ESI-IT-MS/MS) and nuclear magnetic resonance (NMR). This work is the first study on the chemical composition of P. catharinea and encourages the production of Plantago species as a good source of bioactive molecules. (AU)

• Processo FAPESP: 09/52237-9 - Fitoterápicos padronizados como alvo para o tratamento de doenças crônicas
• Beneficiário: Wagner Vilegas
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 11/23113-0 - Estruturas secretoras de Plantago: morfologia estrutural e química: um estudo foliar comparado
• Beneficiário: Leonardo Mendes de Souza Mesquita
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/07681-3 - Isolamento e identificação de metabólitos secundários foliares de Plantago catharinea (Plantaginaceae)
• Beneficiário: Leonardo Mendes de Souza Mesquita
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica