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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes

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Autor(es):
Nunes, Rafael Almeida ; Mazzotti, Diego Robles ; Hirotsu, Camila ; Andersen, Monica L. ; Tufik, Sergio ; Bittencourt, Lia
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: Sleep Medicine; v. 30, p. 210-215, FEB 2017.
Citações Web of Science: 4
Resumo

Objective: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from Sao Paulo, Brazil. Methods: This study was conducted in participants of the Sao Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from Sao Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study. Results: We found that caffeine consumption was positively correlated with sleep latency and a spectral power, as well as negatively correlated with percentage of N3 stage and delta spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype. Conclusion: Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs