Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies

Autor(es)

Furtado, Niege A. J. C. ; Pirson, Laetitia ; Edelberg, Helene ; Miranda, Lisa M. ; Loira-Pastoriza, Cristina ; Preat, Veronique ; Larondelle, Yvan ; Andre, Christelle M.

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 22, n. 3 MAR 2017.
• Citações Web of Science: 16

Resumo

Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of the human diet. The beneficial health effects of edible and medicinal plants have partly been associated with their triterpene content, but the in vivo efficacy in humans depends on many factors, including absorption and metabolism. This review presents an overview of in vitro and in vivo studies that were carried out to determine the bioavailability of pentacyclic triterpenes and highlights the efforts that have been performed to improve the dissolution properties and absorption of these compounds. As plant matrices play a critical role in triterpene bioaccessibility, this review covers literature data on the bioavailability of pentacyclic triterpenes ingested either from foods and medicinal plants or in their free form. (AU)

• Processo FAPESP: 14/17479-0 - Estudos de bioacessibilidade, transporte intestinal e metabolismo de fases I, II e III in vitro de triterpenos pentacíclicos de cultivares de Malus domestica Borkh
• Beneficiário: Niege Araçari Jacometti Cardoso Furtado
• Modalidade de apoio: Bolsas no Exterior - Pesquisa