Use of autogenous bone and beta-tricalcium phosphate in maxillary sinus lifting: histomorphometric study and immunohi'stochemical assessment of RUNX2 and VEGF

Autor(es)

Pereira, R. S. ; Gorla, L. F. ; Boos, F. B. J. D. ; Okamoto, R. ; Garcia Junior, I. R. ; Hochuli-Vieira, E.

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Oral and Maxillofacial Surgery; v. 46, n. 4, p. 503-510, APR 2017.
• Citações Web of Science: 8

Resumo

The aim of this study was to compare the use of beta-tricalcium phosphate (beta-TCP) (chronOS) with autogenous bone grafts alone in maxillary sinus elevation surgery. The test samples were beta-TCP alone, beta-TCP mixed with autogenous bone grafts (1:1), and autogenous bone grafts alone. Twelve maxillary sinuses were grafted with beta-TCP (group 1), nine with beta-TCP + autogenous bone graft (group 2), and 12 with autogenous bone graft (group 3). After 6 months, biopsies were obtained concurrent to the placement of dental implants; these were subjected to histomorphometric analysis and immunohistochemical analysis for runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF). The average bone formation in group 1 was 46.3 +/- 11.6% in the pristine bone region, 47.6 +/- 9.9% in the intermediate region, and 44.8 +/- 22.1% in the apical region; in group 2, values were 35.0 + 15.8%, 32.5 +/- 13.7%, and 32.8 +/- 16.0%, respectively; in group 3, values were 43.1 16.0%, 31.0 13.0%, and 46.1 16.3%, respectively. Immunostaining of samples in group 2 showed high cellular activity and immature bone; this differed from groups 1 and 3, in which mature bone was demonstrated. Thus, this study showed that beta-TCP presents the same behaviour as autogenous bone graft, which makes it a good bone substitute. (AU)

• Processo FAPESP: 12/08455-4 - Análise tomográfica, histológica, histométrica e imunoistoquímica do beta tricálcio fosfato com osso autógeno em aumento do soalho de seio maxilar
• Beneficiário: Rodrigo dos Santos Pereira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/10028-7 - Estudo comparativo do processo de reparo utilizando osso autógeno e beta-tricálcio fosfato em levantamento de seio maxilar em humanos: análise tomográfica, histológica, histométrica e imunoistoquímica
• Beneficiário: Eduardo Hochuli Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular