Antimicrobial activity and acute toxicity of ozonated lomefloxacin solution

Autor(es)

Duarte de Oliveira, Amanda Marchi ; Maniero, Milena Guedes ; Rodrigues-Silva, Caio ; Guimaraes, Jose Roberto

• Tipo de documento: Artigo Científico
• Fonte: Environmental Science and Pollution Research; v. 24, n. 7, p. 6252-6260, MAR 2017.
• Citações Web of Science: 5

Resumo

Lomefloxacin (LOM) is a synthetic antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its antimicrobial activity. This study evaluated the effect of ozonation of LOM (500 mu g L-1), the residual antimicrobial activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L-1 O-3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L-1 O-3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the antimicrobial activity of the solution dropped as ozone dose increased (antimicrobial activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in antimicrobial activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O-3) that acted the most in the process. (AU)

• Processo FAPESP: 13/04656-8 - Degradação de fármacos por peroxidação assistida por radiação ultravioleta e ozonização: atividade antimicrobiana e toxicidade
• Beneficiário: José Roberto Guimarães
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/09543-7 - Resíduos de medicamentos veterinários no ambiente
• Beneficiário: Susanne Rath
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07817-2 - Degradação de sulfonamidas e tetraciclinas por UV/H2O2 e O3: avaliação da atividade antimicrobiana e da toxicidade
• Beneficiário: Milena Guedes Maniero Ferreira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/16622-3 - Identificação dos intermediários formados durante a degradação de fármacos veterinários por processos oxidativos avançados
• Beneficiário: Caio Alexandre Augusto Rodrigues da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado