| Full text | |
| Author(s): |
Duarte de Oliveira, Amanda Marchi
;
Maniero, Milena Guedes
;
Rodrigues-Silva, Caio
;
Guimaraes, Jose Roberto
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Environmental Science and Pollution Research; v. 24, n. 7, p. 6252-6260, MAR 2017. |
| Web of Science Citations: | 5 |
| Abstract | |
Lomefloxacin (LOM) is a synthetic antimicrobial from the fluoroquinolone family (FQ) used as a veterinary and human drug. Once in the environment, LOM may pose a risk to aquatic and terrestrial microorganisms due to its antimicrobial activity. This study evaluated the effect of ozonation of LOM (500 mu g L-1), the residual antimicrobial activity against Escherichia coli and acute toxicity against Vibrio fischeri. In addition, degradation products were investigated by UHPLC-MS/MS and proposed. Ozonation was carried out varying the applied ozone dose from 0 to 54.0 mg L-1 O-3 and pH values of 3, 7, and 11. Ozonation was most efficient at pH 11 and led to 92.8% abatement of LOM in a 9-min reaction time (54.0 mg L-1 O-3 applied ozone dose). Ozonation at pH 3 was able to degrade 80.4% of LOM. At pH 7, 74.3% of LOM was degraded. Although the LOM concentration and the antimicrobial activity of the solution dropped as ozone dose increased (antimicrobial activity reduction of 95% at pH 11), toxicity to V. fischeri increased for pH 7 and 11 (i.e., 65% at pH 7 and 75% at pH 11). The reduction in antimicrobial activity may be related to the oxidation of piperazinyl and the quinolone moiety. The formation of intermediates depended on the oxidant (hydroxyl radicals or/and molecular O-3) that acted the most in the process. (AU) | |
| FAPESP's process: | 13/04656-8 - Degradation of pharmaceuticals by peroxidation combined with ultraviolet radiation and ozonation: antimicrobial activity and toxicity |
| Grantee: | José Roberto Guimarães |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/09543-7 - Residues of veterinary drugs in the environment |
| Grantee: | Susanne Rath |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07817-2 - Degradation of sulfonamides and tetraciclines by UV/H2O2 and O3: evaluation of antimicrobial activity and toxicity |
| Grantee: | Milena Guedes Maniero Ferreira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/16622-3 - Identification of intermediates formed during degradation of veterinary drugs by advanced oxidation processes |
| Grantee: | Caio Alexandre Augusto Rodrigues da Silva |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |