| Texto completo | |
| Autor(es): |
Lima, Leandro B.
;
Bueno, Debora
;
Leite, Fernanda
;
Souza, Stefani
;
Goncalves, Luciano
;
Furigo, Isadora C.
;
Donato, Jr., Jose
;
Metzger, Martin
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF COMPARATIVE NEUROLOGY; v. 525, n. 10, p. 2411-2442, JUL 1 2017. |
| Citações Web of Science: | 17 |
| Resumo | |
The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). Recently, MHb together with its primary target, the interpeduncular nucleus (IP), have been identified as major players in mediating the aversive effects of nicotine. However, structures downstream of the MHb-IP axis, including the median (MnR) and caudal dorsal raphe nucleus (DRC), may contribute to the behavioral effects of nicotine. The afferent and efferent connections of the IP have hitherto not been systematically investigated with sensitive tracers. Thus, we placed injections of retrograde or anterograde tracers into different IP subdivisions or the MnR and additionally examined the transmitter phenotype of major IP and MnR afferents by combining retrograde tract tracing with immunofluorescence and in situ hybridization techniques. Besides receiving inputs from MHb and also LHb, we found that IP is reciprocally interconnected mainly with midline structures, including the MnR/DRC, nucleus incertus, supramammillary nucleus, septum, and laterodorsal tegmental nucleus. The bidirectional connections between IP and MnR proved to be primarily GABAergic. Regarding a possible topography of IP outputs, all IP subnuclei gave rise to descending projections, whereas major ascending projections, including focal projections to ventral hippocampus, ventrolateral septum, and LHb originated from the dorsocaudal IP. Our findings indicate that IP is closely associated to a distributed network of midline structures that modulate hippocampal theta activity and forms a node linking MHb and LHb with this network, and the hippocampus. Moreover, they support a cardinal role of GABAergic IP/MnR interconnections in the behavioral response to nicotine. (AU) | |
| Processo FAPESP: | 13/21722-4 - Estudo do mecanismo de ação da Bromocriptina e de antagonistas de prolactina no tratamento do Diabetes Mellitus tipo 2 e da Obesidade. |
| Beneficiário: | Isadora Clivatti Furigo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 10/18086-0 - Bases moleculares da resistência à leptina |
| Beneficiário: | Jose Donato Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 12/02388-3 - Topografia e assinatura neuroquímica das projeções entre a habênula lateral, o núcleo rostromedial tegmental e o núcleo dorsal da rafe no rato |
| Beneficiário: | Martin Andreas Metzger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |