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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Morphological variability of the arterial valve in common arterial trunk and the concept of normality

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Autor(es):
Liguori, Gabriel Romero ; Jatene, Marcelo Biscegli ; Ho, Siew Yen ; Aiello, Vera Demarchi
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: HEART; v. 103, n. 11, p. 848-855, JUN 2017.
Citações Web of Science: 1
Resumo

Objective Until now, no study established a morphometric evaluation of the truncal valve dysplasia and a description of its different presentation patterns. Thus, authors conducted an anatomopathological study describing the gross features and histological findings of the truncal valve. Methods 50 common arterial trunk (CAT) specimens were examined. The number of valvar leaflets was determined and valvar dysplasia was classified as absent, mild, moderate or severe. Selected leaflets were sectioned and submitted to histological analysis and linear measurements (thickness, length and area), besides quantification of collagen area fraction. Results 28 (56%) valves presented three, 15 (30%) four and 7 (14%) two leaflets. Valvar dysplasia was absent in 13 (26%) cases, mild in 19 (38%), moderate in 6 (12%) and severe in 12 (24%). A significant association was found between the presence of four leaflets and valvar dysplasia (p<0.001). Single coronary ostium was more common in two-leaflet cases than in three-leaflet cases (p=0.037). Leaflets medial thirds were thicker in the more dysplastic valves (p=0.006) and in those presenting anarchic collagen distribution (p=0.002). Conclusions CAT semilunar valves present two main patterns. The first characterised by three leaflets and absent or mild dysplasia and the second by four leaflets and severe dysplasia. Still, great variability regarding thickness, microscopic organisation of the extracellular matrix and proportions of leaflets' dimensions exists, which may impact on the surgical outcomes. (AU)

Processo FAPESP: 12/06735-0 - Características morfológicas da valva truncal e das outras anomalias associadas ao tronco arterial comum persistente
Beneficiário:Gabriel Romero Liguori
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica
Processo FAPESP: 10/16811-0 - Morfologia histológica das válvulas semilunares no tronco arterial comum persistente e sua relação com outras características morfológicas da anomalia congênita
Beneficiário:Gabriel Romero Liguori
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 10/16663-0 - Morfologia histológica das válvulas semilunares no tronco arterial comum persistente e sua relação com outras características morfológicas da anomalia congênita
Beneficiário:Vera Demarchi Aiello
Linha de fomento: Auxílio à Pesquisa - Regular