Shorter leukocyte telomere length in patients at ultra high risk for psychosis

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Maurya, Pawan Kumar ; Rizzo, Lucas Bortolotto ; Xavier, Gabriela ; Tempaku, Priscila Farias ; Zeni-Graiff, Maiara ; Santoro, Marcos L. ; Mazzotti, Diego Robles ; Zugman, Andre ; Pan, Pedro ; Noto, Cristiano ; Maes, Michael ; Asevedo, Elson ; Mansur, Rodrigo B. ; Cunha, Graccielle R. ; Gadelha, Ary ; Bressan, Rodrigo A. ; Belangero, Sintia Iole ; Brietzke, Elisa

• Tipo de documento: Artigo Científico
• Fonte: European Neuropsychopharmacology; v. 27, n. 5, p. 538-542, MAY 2017.
• Citações Web of Science: 12

Resumo

Telomere length attrition has been demonstrated in schizophrenia but not in individuals in ultra high risk (UHR) for psychosis. The present study aimed to compare the leukocyte telomere length (TL) between patients at UHR for psychosis and healthy controls (HC). Twenty-two participants with UHR and 88 HC were enrolled in this study. Telomere lengths were determined using a multiplex qPCR assay. After adjustment for age, sex, ethnicity, and education, patients in UHR, compared with HC groups, had shorter telomere length (RR: 0.929, p=0.031). Shorter leukocyte telomere length in UHR could represent early signs of accelerated aging in this population. (C) 2017 Elsevier B.V. and ECNP. All rights reserved. (AU)

• Processo FAPESP: 14/07280-1 - Busca por marcadores genéticos de risco, de progressão e de reposta ao tratamento na esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular