The anti-inflammatory effect of tramadol in the temporomandibular joint of rats

Autor(es)

Lamana, Simone Monaliza S. ; Napimoga, Marcelo H. ; Camatta Nascimento, Ana Paula ; Freitas, Fabiana F. ; de Araujo, Daniele R. ; Quinteiro, Mariana S. ; Macedo, Cristina G. ; Fogaca, Carlos L. ; Clemente-Napimoga, Juliana T.

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmacology; v. 807, p. 82-90, JUL 15 2017.
• Citações Web of Science: 8

Resumo

Tramadol is a centrally acting analgesic drug able to prevent nociceptor sensitization when administered into the temporomandibular joint (TMJ) of rats. The mechanism underlying the peripheral anti-inflammatory effect of tramadol remains unknown. This study demonstrated that intra-TMJ injection of tramadol (500 mu g/TMJ) was able to inhibit the nociceptive response induced by 1.5% formalin or 1.5% capsaicin, suggesting that tramadol has an antinociceptive effect, acting directly on the primary nociceptive neurons activating the nitric oxide/cyclic guanosine monophosphate signaling pathway. Tramadol also inhibited the nociceptive response induced by carrageenan (100 mu g/TMJ) or 5-hydroxytryptamine (225 mu g/TMJ) along with inhibition of inflammatory cytokines levels, leukocytes migration and plasma extravasation. In conclusion, the results demonstrate that peripheral administration of tramadol has a potential antinociceptive and anti-inflammatory effect. The antinociceptive effect is mediated by activation of the intracellular nitric oxide/cyclic guanosine monophosphate pathway, at least in part, independently from the opioid system. (AU)

• Processo FAPESP: 13/11090-0 - Avaliação do efeito periférico anti-inflamatório do tramadol na articulação temporomandibular de ratos.
• Beneficiário: Simone Monaliza Silva Lamana
• Modalidade de apoio: Bolsas no Brasil - Doutorado