The anti-inflammatory effect of tramadol in the temporomandibular joint of rats

Author(s)

Lamana, Simone Monaliza S. ; Napimoga, Marcelo H. ; Camatta Nascimento, Ana Paula ; Freitas, Fabiana F. ; de Araujo, Daniele R. ; Quinteiro, Mariana S. ; Macedo, Cristina G. ; Fogaca, Carlos L. ; Clemente-Napimoga, Juliana T.

• Document type: Journal article
• Source: European Journal of Pharmacology; v. 807, p. 82-90, JUL 15 2017.
• Web of Science Citations: 8

Abstract

Tramadol is a centrally acting analgesic drug able to prevent nociceptor sensitization when administered into the temporomandibular joint (TMJ) of rats. The mechanism underlying the peripheral anti-inflammatory effect of tramadol remains unknown. This study demonstrated that intra-TMJ injection of tramadol (500 mu g/TMJ) was able to inhibit the nociceptive response induced by 1.5% formalin or 1.5% capsaicin, suggesting that tramadol has an antinociceptive effect, acting directly on the primary nociceptive neurons activating the nitric oxide/cyclic guanosine monophosphate signaling pathway. Tramadol also inhibited the nociceptive response induced by carrageenan (100 mu g/TMJ) or 5-hydroxytryptamine (225 mu g/TMJ) along with inhibition of inflammatory cytokines levels, leukocytes migration and plasma extravasation. In conclusion, the results demonstrate that peripheral administration of tramadol has a potential antinociceptive and anti-inflammatory effect. The antinociceptive effect is mediated by activation of the intracellular nitric oxide/cyclic guanosine monophosphate pathway, at least in part, independently from the opioid system. (AU)

• FAPESP's process: 13/11090-0 - ASSESSMENT OF ANTI-INFLAMMATORY EFFECT OF PERIPHERAL TRAMADOL IN THE TEMPOROMANDIBULAR JOINT IN RATS.
• Grantee: Simone Monaliza Silva Lamana
• Support Opportunities: Scholarships in Brazil - Doctorate