ASSESSMENT OF ANTI-INFLAMMATORY EFFECT OF PERIPHERAL TRAMADOL IN THE TEMPOROMANDIBULAR JOINT IN RATS.

• Grant number: 13/11090-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2013
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Juliana Trindade Clemente Napimoga
• Grantee: Simone Monaliza Silva Lamana
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Tramadol hydrochloride is a central-action analgesic drug which administered peripherally has shown potent analgesic. It was shown in a pilot study which tramadol, when administered in the temporomandibular joint (TMJ), induces a potent antinociceptive through activation of the NO/ cGMP pathway. It has happened independent activation of opioid receptors, however. Whereas activation L-Arginine/NO/cGMP peripheral pathway decreases hypernociception process using a negative feedback control, it is possible that the tramadol analgesic effect in the TMJ is related to an anti-inflammatory effect indirectly. Therefore, the proposed project aims to evaluate the effect of Tramadol in peripheral inflammatory hypernociception induced by carrageenan and serotonin in rats' TMJ through nociceptive behavioral analysis, migration of inflammatory cells, plasma extravasation, release of cytokines and chemokines TNF -±, IL-1², IL-10 and KC, and the involvement of macrophages resident in the anti-inflammatory effect induced by Tramadol rats' TMJ.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAMANA, SIMONE MONALIZA S.; NAPIMOGA, MARCELO H.; CAMATTA NASCIMENTO, ANA PAULA; FREITAS, FABIANA F.; DE ARAUJO, DANIELE R.; QUINTEIRO, MARIANA S.; MACEDO, CRISTINA G.; FOGACA, CARLOS L.; CLEMENTE-NAPIMOGA, JULIANA T.. The anti-inflammatory effect of tramadol in the temporomandibular joint of rats. European Journal of Pharmacology, v. 807, p. 82-90, JUL 15 2017. (13/11090-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LAMANA, Simone Monaliza Silva. Mechanisms involved in the peripheral antiinflammatory effect of tramadol into rat's temporomandibular joint. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.