Tramadol hydrochloride is a central-action analgesic drug which administered peripherally has shown potent analgesic. It was shown in a pilot study which tramadol, when administered in the temporomandibular joint (TMJ), induces a potent antinociceptive through activation of the NO/ cGMP pathway. It has happened independent activation of opioid receptors, however. Whereas activation L-Arginine/NO/cGMP peripheral pathway decreases hypernociception process using a negative feedback control, it is possible that the tramadol analgesic effect in the TMJ is related to an anti-inflammatory effect indirectly. Therefore, the proposed project aims to evaluate the effect of Tramadol in peripheral inflammatory hypernociception induced by carrageenan and serotonin in rats' TMJ through nociceptive behavioral analysis, migration of inflammatory cells, plasma extravasation, release of cytokines and chemokines TNF -±, IL-1², IL-10 and KC, and the involvement of macrophages resident in the anti-inflammatory effect induced by Tramadol rats' TMJ.
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