Using a system of differential equations that models cattle growth to uncover the genetic basis of complex traits

Autor(es)

Freua, Mateus Castelani ; de Almeida Santana, Miguel Henrique ; Ventura, Ricardo Vieira ; Tedeschi, Luis Orlindo ; Sterman Ferraz, Jose Bento

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF APPLIED GENETICS; v. 58, n. 3, p. 393-400, AUG 2017.
• Citações Web of Science: 0

Resumo

The interplay between dynamic models of biological systems and genomics is based on the assumption that genetic variation of the complex trait (i.e., outcome of model behavior) arises from component traits (i.e., model parameters) in lower hierarchical levels. In order to provide a proof of concept of this statement for a cattle growth model, we ask whether model parameters map genomic regions that harbor quantitative trait loci (QTLs) already described for the complex trait. We conducted a genome-wide association study (GWAS) with a Bayesian hierarchical LASSO method in two parameters of the Davis Growth Model, a system of three ordinary differential equations describing DNA accretion, protein synthesis and degradation, and fat synthesis. Phenotypic and genotypic data were available for 893 Nellore (Bos indicus) cattle. Computed values for parameter k(1) (DNA accretion rate) ranged from 0.005 +/- 0.003 and for alpha (constant for energy for maintenance requirement) 0.134 +/- 0.024. The expected biological interpretation of the parameters is confirmed by QTLs mapped for k(1) and alpha. QTLs within genomic regions mapped for k(1) are expected to be correlated with the DNA pool: body size and weight. Single nucleotide polymorphisms (SNPs) which were significant for alpha mapped QTLs that had already been associated with residual feed intake, feed conversion ratio, average daily gain (ADG), body weight, and also dry matter intake. SNPs identified for k(1) were able to additionally explain 2.2% of the phenotypic variability of the complex ADG, even when SNPs for k(1) did not match the genomic regions associated with ADG. Although improvements are needed, our findings suggest that genomic analysis on component traits may help to uncover the genetic basis of more complex traits, particularly when lower biological hierarchies are mechanistically described by mathematical simulation models. (AU)

• Processo FAPESP: 13/20571-2 - Genômica funcional da ingestão e eficiência alimentar de bovinos da raça Nelore
• Beneficiário: Miguel Henrique de Almeida Santana
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/26902-0 - Uso da variância genética em modelos mecanicistas dinâmicos de crescimento para predizer o desempenho e a composição da carcaça de bovinos confinados
• Beneficiário: Mateus Castelani Freua
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/07566-2 - Genômica aplicada à produção de ruminantes
• Beneficiário: José Bento Sterman Ferraz
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/02039-9 - Estudo genômico da ingestão e eficiência alimentar em bovinos da raça Nelore
• Beneficiário: José Bento Sterman Ferraz
• Linha de fomento: Auxílio à Pesquisa - Regular