Prognostic biomarkers in oral squamous cell carcinoma: A systematic review

Autor(es)

Rivera, Cesar ; Oliveira, Ana Karina ; Pereira Costa, Rute Alves ; De Rossi, Tatiane ; Paes Leme, Adriana Franco

• Tipo de documento: Artigo de Revisão
• Fonte: Oral Oncology; v. 72, p. 38-47, SEP 2017.
• Citações Web of Science: 18

Resumo

Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, diseasefree survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/12431-1 - Verificação de proteínas da saliva candidatas a marcadores em CEC e sua correlação com o prognóstico
• Beneficiário: Tatiane de Rossi Mazo
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/07846-0 - Análise peptidômica de vesículas extracelulares originadas de linhagens celulares, saliva e plasma de pacientes com carcinoma de células escamosas da cavidade oral
• Beneficiário: Adriana Franco Paes Leme
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/06485-9 - Investigação do mecanismo de regulação da metaloproteinase ADAM17 pela interação com Trx-1
• Beneficiário: Rute Alves Pereira e Costa
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado