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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency

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Autor(es):
Piovezan, Ronaldo D. ; Hirotsu, Camila ; Feres, Marcia C. ; Cintra, Fatima D. ; Andersen, Monica L. ; Tufik, Sergio ; Poyares, Dalva
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: PLoS One; v. 12, n. 7 JUL 7 2017.
Citações Web of Science: 10
Resumo

`Background Studies demonstrate an association between vitamin D (25(OH) D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH) D. Objectives To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH) D in an adult population sample. Methods A cross-sectional study included 657 individuals from the city of Sao Paulo, Brazil, as part of the ERA project. Participants fulfilled questionnaires and underwent clinical evaluation, polysomnography and blood sample collection for 25(OH) D quantification. OSA was classified into three categories (mild, moderate and severe). The risk of 25(OH) D deficiency was considered as levels<30 ng/mL. Short sleep duration was defined as total sleep time<6 hours. Results The risk of 25(OH) D deficiency was observed in 59.5% of the sample, affecting more individuals of the female gender, obese, with African American ethnicity, and those that were smokers, sedentary and presented hypertension and diabetes. In the final logistic model adjusted for age, gender, ethnicity, obesity, smoking, hypertension, diabetes, sedentary lifestyle, seasonality and creatinine serum levels, both OSA and short sleep duration showed significant independent associations with the risk of 25(OH) D deficiency (moderate OSA: OR for 25(OH) D<30 = 2.21, 95% CI: 1.35-3.64, p<0.01; severe OSA: OR for 25(OH) D<30 = 1.78, 95% CI: 1.06-3.00, p = 0.03; short sleep duration: OR for 25(OH) D<30 = 1.61, 95% CI: 1.15-2.26, p = 0.01). After a subgroup analysis, similar results were observed only in participants >= 50 years. Conclusion OSA and short sleep duration are independently associated with the risk of 25(OH) D deficiency in an adult population. Age-related changes in vitamin D metabolism and the frequency of sleep disorders may be involved in these associations. Future studies exploring whether 25(OH) D levels may modulate OSA and sleep curtailment-related outcomes are needed. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 14/15259-2 - Epidemiologia do sono na Cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Pós-Doutorado