Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats

Texto completo
Autor(es):
Mostrar menos -
Parreiras-e-Silva, Lucas T. ; Vargas-Pinilla, Pedro ; Duarte, Diego A. ; Longo, Danae ; Espinoza Pardo, Grace Violeta ; Finkler, Andrea Dulor ; Paixao-Cortes, Vanessa Rodrigues ; Pare, Pamela ; Rovaris, Diego L. ; Oliveira, Eduardo B. ; Caceres, Rafael Andrade ; Goncalves, Gislene L. ; Bouvier, Michel ; Salzano, Francisco M. ; Lucion, Aldo B. ; Costa-Neto, Claudio M. ; Bortolini, Maria Catira
Número total de Autores: 17
Tipo de documento: Artigo Científico
Fonte: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 114, n. 34, p. 9044-9049, AUG 22 2017.
Citações Web of Science: 13
Resumo

The neurohormone oxytocin is a key player in the modulation of reproductive and social behavioral traits, such as parental care. Recently, a correlation between different forms of oxytocin and behavioral phenotypes has been described in the New World Monkeys (NWMs). Here, we demonstrate that, compared with the Leu(8)OXT found in most placental mammals, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific variants act as equiefficacious agonists for the Gq-dependent pathway but are weaker agonists for the beta-arrestin engagement and subsequent endocytosis toward the oxytocin receptor (OXTR). Upon interaction with the AVPR(1)a, Pro(8)OXT and the common Leu(8)OXT yielded similar signaling profiles, being equally efficacious on Gq and beta-arrestin, while Val(3)Pro(8)OXT showed reduced relative efficacy toward beta-arrestin. Intranasal treatment with either of the variants increased maternal behavior and also promoted unusual paternal care in rats, as measured by pup-retrieval tests. We therefore suggest that Val(3)Pro(8)OXT and Pro(8)OXT are functional variants, which might have been evolutionarily co-opted as an essential part of the adaptive genetic repertoire that allowed the emergence of taxon-specific complex social behaviors, such as intense parental care in the Cebidae and the genus Saguinus. (AU)

Processo FAPESP: 15/50086-4 - Development of biosensors for monitoring signaling in subcellular compartments: a powerful molecular tool for drug discovery
Beneficiário:Claudio Miguel da Costa Neto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/20148-0 - Desenvolvimento de novos ligantes/drogas com ação agonística seletiva ("biased agonism") para receptores dos sistemas renina-angiotensina e calicreínas-cininas: novas propriedades e novas aplicações biotecnológicas
Beneficiário:Claudio Miguel da Costa Neto
Linha de fomento: Auxílio à Pesquisa - Temático