On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells

Autor(es):Mostrar menos -

Gontijo, Talita B. ; de Freitas, Rossimiriam P. ; Emery, Flavio S. ; Pedrosa, Leandro F. ; Vieira Neto, Jose B. ; Cavalcanti, Bruno C. ; Pessoa, Claudia ; King, Aaron ; de Moliner, Fabio ; Vendrell, Marc ; da Silva Junior, Eufrnio N.

• Tipo de documento: Artigo Científico
• Fonte: Bioorganic & Medicinal Chemistry Letters; v. 27, n. 18, p. 4446-4456, SEP 15 2017.
• Citações Web of Science: 7

Resumo

Fluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR analysis and mass spectrometry. We measured their cytotoxic activity against cancer and normal cell lines, performed mechanistic studies by lipid peroxidation and determination of reduced (GSH) and oxidized (GSSG) glutathione, and imaged their subcellular localisation by confocal microscopy. Cell imaging experiments indicated that nor-beta-lapachone-based BODIPY derivatives might preferentially localise in the lysosomes of cancer cells. These results assert the potential of hybrid quinone-BODIPY derivatives as promising prototypes in the search of new potent lapachone antitumor drugs. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 14/22451-7 - Sistemas de liberação sustentada e direcionada de fármacos para o tecido epitelial
• Beneficiário: Renata Fonseca Vianna Lopez
• Modalidade de apoio: Auxílio à Pesquisa - Temático