The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome

Autor(es)

Rodrigues, Sara ; Cepeda, Felipe X. ; Toschi-Dias, Edgar ; Dutra-Marques, Akothirene C. B. ; Carvalho, Jefferson C. ; Costa-Hong, Valeria ; Alves, Maria Janieire N. N. ; Rondon, Maria Urbana P. B. ; Bortolotto, Luiz A. ; Trombetta, Ivani C.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL HYPERTENSION; v. 19, n. 9, p. 840-847, SEP 2017.
• Citações Web of Science: 2

Resumo

Metabolic syndrome (MetS) causes autonomic alteration and vascular dysfunction. The authors investigated whether impaired fasting glucose (IFG) is the main cause of vascular dysfunction via elevated sympathetic tone in nondiabetic patients with MetS. Pulse wave velocity, muscle sympathetic nerve activity (MSNA), and forearm vascular resistance was measured in patients with MetS divided according to fasting glucose levels: (1) MetS+IFG (blood glucose 100mg/dL) and (2) MetS-IFG (<100mg/dL) compared with healthy controls. Patients with MetS+IFG had higher pulse wave velocity than patients with MetS-IFG and controls (median 8.0 {[}interquartile range, 7.2-8.6], 7.3 {[}interquartile range, 6.9-7.9], and 6.9 {[}interquartile range, 6.6-7.2] m/s, P=.001). Patients with MetS+IFG had higher MSNA than patients with MetS-IFG and controls, and patients with MetS-IFG had higher MSNA than controls (31 +/- 1, 26 +/- 1, and 19 +/- 1 bursts per minute; P<.001). Patients with MetS+IFG were similar to patients with MetS-IFG but had higher forearm vascular resistance than controls (P=.008). IFG was the only predictor variable of MSNA. MSNA was associated with pulse wave velocity (R=.39, P=.002) and forearm vascular resistance (R=.30, P=.034). In patients with MetS, increased plasma glucose levels leads to an adrenergic burden that can explain vascular dysfunction. (AU)

• Processo FAPESP: 11/17533-6 - Aspectos autonômicos, metabólicos e inflamatórios da associação da síndrome metabólica com a apnéia obstrutiva do sono: efeito da dieta hipocalórica e do treinamento físico
• Beneficiário: Ivani Credidio Trombetta
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/03274-0 - Marcadores metabólicos/inflamatórios e balanço simpato-vagal em pacientes com síndrome metabólica e apneia obstrutiva do sono: efeito da dieta hipocalórica e treinamento físico
• Beneficiário: Felipe Xerez Cepêda Fonseca
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/15323-0 - Rigidez arterial e resistência vascular periférica na síndrome metabólica : efeito da dieta hipocalórica associada ao treinamento físico
• Beneficiário: Sara Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/07651-7 - Valor prognóstico do padrão oscilatório da atividade nervosa simpática muscular em pacientes com insuficiência cardíaca
• Beneficiário: Edgar Toschi Dias
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado