The role of increased glucose on neurovascular dysfunction in patients with the metabolic syndrome

Author(s)

Rodrigues, Sara ; Cepeda, Felipe X. ; Toschi-Dias, Edgar ; Dutra-Marques, Akothirene C. B. ; Carvalho, Jefferson C. ; Costa-Hong, Valeria ; Alves, Maria Janieire N. N. ; Rondon, Maria Urbana P. B. ; Bortolotto, Luiz A. ; Trombetta, Ivani C.

• Document type: Journal article
• Source: JOURNAL OF CLINICAL HYPERTENSION; v. 19, n. 9, p. 840-847, SEP 2017.
• Web of Science Citations: 2

Abstract

Metabolic syndrome (MetS) causes autonomic alteration and vascular dysfunction. The authors investigated whether impaired fasting glucose (IFG) is the main cause of vascular dysfunction via elevated sympathetic tone in nondiabetic patients with MetS. Pulse wave velocity, muscle sympathetic nerve activity (MSNA), and forearm vascular resistance was measured in patients with MetS divided according to fasting glucose levels: (1) MetS+IFG (blood glucose 100mg/dL) and (2) MetS-IFG (<100mg/dL) compared with healthy controls. Patients with MetS+IFG had higher pulse wave velocity than patients with MetS-IFG and controls (median 8.0 {[}interquartile range, 7.2-8.6], 7.3 {[}interquartile range, 6.9-7.9], and 6.9 {[}interquartile range, 6.6-7.2] m/s, P=.001). Patients with MetS+IFG had higher MSNA than patients with MetS-IFG and controls, and patients with MetS-IFG had higher MSNA than controls (31 +/- 1, 26 +/- 1, and 19 +/- 1 bursts per minute; P<.001). Patients with MetS+IFG were similar to patients with MetS-IFG but had higher forearm vascular resistance than controls (P=.008). IFG was the only predictor variable of MSNA. MSNA was associated with pulse wave velocity (R=.39, P=.002) and forearm vascular resistance (R=.30, P=.034). In patients with MetS, increased plasma glucose levels leads to an adrenergic burden that can explain vascular dysfunction. (AU)

• FAPESP's process: 11/17533-6 - Autonomic, metabolic and inflammatory aspects of metabolic syndrome associated with obstructive sleep apnea: effect of hypocaloric diet and physical training
• Grantee: Ivani Credidio Trombetta
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/03274-0 - Diet and exercise improves metabolic, inflammatory changes and sympathovagal balance in patients with metabolic syndrome and obstructive sleep apnea
• Grantee: Felipe Xerez Cepêda Fonseca
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/15323-0 - Arterial stiffness and vascular resistance in patients with metabolic syndrome: effect of hypocaloric diet associated with exercise training
• Grantee: Sara Rodrigues
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/07651-7 - Prognostic value of the oscillatory pattern of muscle sympathetic nerve activity in patients with heart failure
• Grantee: Edgar Toschi Dias
• Support Opportunities: Scholarships in Brazil - Post-Doctoral