SummaryMetabolic syndrome (MetS) is characterized by overlapping of risk factors such as dyslipidemia, hypertension, insulin resistance and visceral obesity. Independently, these factors cause morphological and functional changes in the vascular system, which directly relate to increased risk of cardiovascular events and death. This study aims to: 1) identify any impairment on central and peripheral vascular morphology/function in subjects with MetS; 2) investigate whether there is a relationship between the injury in these two beds, and 3) determine the effect of weight loss and increased physical capacity obtained by hypocaloric diet and exercise training specifically in the arterial stiffness, intima-media thickness, peripheral vascular resistance and blood pressure. Patients with MetS (according to ATP-III) will be divided into 2 groups: control group for intervention (MetS/C n=14), with only clinical follow-up, and intervention group, (MetS/TF+D +, where: D=decrease 500 Kcal/day; and TF=3 times/week, 50-70% VO2peak, n=14) which will be submitted to diet and physical training for 4 months. A healthy control group matched for age and gender will also be involved in the study (C=10). Will be assessed: body composition (bioelectrical impedance), clinical profile and metabolic fitness (ergospirometry), muscle blood flow (venous oclusion plethysmography), blood pressure (oscillometric), heart rate (ECG), oxygen saturation (pulse oximeter), respiratory rate (piezoeletric), arterial stiffness (pulse wave velocity, PWV) and 24h blood pressure (ambulatory blood pressure measurement, ABPM).
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