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Relaxation and contractile responses of aorta and mesenteric arteries from obese rats supplemented with taurine and trained

Grant number: 10/12733-4
Support type:Regular Research Grants
Duration: January 01, 2011 - June 30, 2013
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Camila de Moraes
Grantee:Camila de Moraes
Home Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Ana Paula Couto Davel ; Ellen Cristini de Freitas


Physical inactivity and diets rich in lipids and sugar are behaviors related to development of obesity and its co-morbidities. High glucose and triglycerides concentration in blood, lead to oxidative stress in vascular bed. This issue might be the link between obesity and cardiovascular diseases. Studies had shown benefits of exercise training regarding to improvements in cardiovascular hemodynamic, such as decrease in peripheral vascular resistance associated to nitric oxide production or bioavailability. None studies were carried out to evaluate taurine supplementation effects on vascular reactivity and pro- and anti-oxidant systems in obese Wistar rats. Therefore, the aim of this study is to evaluate taurine supplementation, together or not with exercise training, on vascular reactivity of high caloric-fed rats. Relaxation and contractile responses as well local and systemic oxidative stress biomarkers will be investigate in obese animals, trained or not. The hypothesis is that taurine has a therapeutic effect against obesity disorders and supplementation together physical exercise might reveal an additionally effect. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OHAROMARI, LEANDRO KANSUKE; GARCIA, NADIA FAGUNDES; DE FREITAS, ELLEN CRISTINI; JORDAO JUNIOR, ALCEU AFONSO; OVIDIO, PAULA PAYAO; MAIA, ALINE ROSA; DAVEL, ANA PAULA; DE MORAES, CAMILA. Exercise training and taurine supplementation reduce oxidative stress and prevent endothelium dysfunction in rats fed a highly palatable diet. Life Sciences, v. 139, p. 91-96, OCT 15 2015. Web of Science Citations: 6.

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