Effects of high-intensity interval exercise with hypoxic recovery and taurine supplementation on metabolic and mitochondrial parameters in women with obesity

• Grant number: 24/01271-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2024
• Effective date (End): July 31, 2028
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ellen Cristini de Freitas
• Grantee: Marcela Coffacci de Lima Viliod
• Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Obesity is recognized as a global pandemic, with Brazil being one of the countries with the highest prevalence rate in Latin America. One of the characteristics associated with obesity is subclinical inflammation. This concentrate, accompanied by adipose tissue hypertrophy, promotes substantial metabolic changes, intensifying oxidative stress and compromising mitochondrial function. Although physical exercise is an extremely restricted non-pharmacological intervention in the fight against obesity, hypoxia appears as an emerging adjuvant modality in recent literature, with the capacity to amplify therapeutic results. In parallel to taurine, a sulfonated amino acid, it has known anti-inflammatory and antioxidant properties. Based on this foundation, this study aims to determine the physiological responses resulting from the combination of physical exercise, recuperative hypoxia and taurine supplementation in adult women with obesity. For this purpose, a muscle biopsy will be performed to investigate cellular respiration, expression of genes associated with oxidative stress and mitochondrial dynamics, as well as blood collection to trace the inflammatory and lipid profile before and after 12 weeks of high-intensity exercise in the ergometer cycle, associated or not. recovery hypoxia and taurine supplementation. It is expected that there will be a reduction in oxidative stress, the addition of nutrients among participants who remain under hypoxia and taurine supplementation, changes in body composition and cardiorespiratory improvement. Among non-supplemented but trained participants, only cardiorespiratory improvement is expected.