Effects of taurine supplementation associated or not to exercise on mitochondrial function, energy expenditure and inflammatory profile in obese women.

• Grant number: 17/08036-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2018
• End date: February 28, 2021
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Ellen Cristini de Freitas
• Grantee: Flávia Giolo De Carvalho
• Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 18/17711-0 - Molecular mechanisms underpinning mitochondrial function across different physical activity and insulin sensitivity levels., BE.EP.PD

Abstract

INTRODUCTION: Taurine supplementation researches has increased due to its antioxidant and anti-inflammatory actions, and its ability to modulate lipid metabolism by stimulating the expression of proteins that regulates mitochondrial biogenesis and increases respiratory function (PGC-1± and PPAR). Since obesity can induce metabolic disorders including abnormal production of adipokines and activation of pro-inflammatory signaling pathways also mitochondrial metabolism dysfunction in the adipose tissue, the use of taurine would be a new strategy for obesity prevention and treatment. Moreover, the association of taurine and exercise could improve exercise effects, promote higher energy expenditure and increase mitochondrial respiration, consequently resulting in weight loss. METHODS: 40 obese women will be recruited for this study. The study will consist of 8-week supplementation period with taurine (3 grams) or placebo associated or not with exercise. In order to check the effects of the intervention, abdominal tissue biopsy will be performed for histological adipose tissue analysis, evaluation of mitochondrial function and quantification of uncoupling proteins (UPCs 1 and 2), PGC 1 ± and PPAR; blood collection will be done for quantification of taurine and of inflammatory markers (IL-10, IL-6, IL-1, TNF-± and CRP) before and after the supplementation period. And body composition will be evaluated by deuterium oxide method. OUTCOMES: It is expected that taurine supplementation associated with exercise will reestablish mitochondrial function of the adipose tissue, increase energy expenditure, decrease weight and body fat mass, and benefit the inflammatory profile of obese women.

Scientific publications

(6)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

BATITUCCI, GABRIELA; CUNHA BRANDAO, CAMILA FERNANDA; DE CARVALHO, FLAVIA GIOLO; MARCHINI, JULIO SERGIO; PFRIMER, KARMA; FERRIOLI, EDUARDO; CUNHA, FERNANDO QUEIROZ; PAPOTI, MARCELO; BARROS MORHY TERRAZAS, SARA IVONE; JUNQUEIRA-FRANCO, MARCIA VARELLA MORANDI; et al. Taurine supplementation increases irisin levels after high intensity physical training in obese women. CYTOKINE, v. 123, NOV 2019. (17/08036-5, 17/10080-2)

DE CARVALHO, FLAVIA G.; JUSTICE, JAMIE N.; DE FREITAS, ELLEN C.; KERSHAW, ERIN E.; SPARKS, LAUREN M.. Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality. NUTRIENTS, v. 11, n. 11, NOV 2019. (17/08036-5, 18/17711-0)

DE CARVALHO, FLAVIA G.; MUNOZ, VITOR R.; BRANDAO, CAMILA F. C.; SIMABUCO, FERNANDO M.; PAVAN, ISADORA C. B.; NAKANDAKARI, SUSANA C. B. R.; PAULI, JOSE RODRIGO; DE MOURA, LEANDRO P.; ROPELLE, EDUARDO R.; MARCHINI, JULIO SERGIO; et al. Taurine upregulates insulin signaling and mitochondrial metabolism in vitro but not in adipocytes of obese women. NUTRITION, v. 93, JAN 2022. (17/08036-5, 17/10080-2)

DE CARVALHO, MILENA BARBON; CUNHA BRANDAO, CAMILA FERNANDA; FASSINI, PRISCILA GIACOMO; BIANCO, THIAGO MANTELLO; BATITUCCI, GABRIELA; MARTINEZ GALAN, BRYAN STEVE; DE CARVALHO, FLAVIA GIOLO; VIEIRA, TALES SAMBRANO; FERRIOLLI, EDUARDO; MARCHINI, JULIO SERGIO; et al. Taurine Supplementation Increases Post-Exercise Lipid Oxidation at Moderate Intensity in Fasted Healthy Males. NUTRIENTS, v. 12, n. 5, MAY 2020. (17/10080-2, 17/08036-5)

DE CARVALHO, FLAVIA GIOLO; CUNHA BRANDAO, CAMILA FERNANDA; MUNOZ, VITOR ROSETTO; BATITUCCI, GABRIELA; DE ALMEIDA TAVARES, MARIA EDUARDA; TEIXEIRA, GIOVANA RAMPAZZO; PAULI, JOSE RODRIGO; DE MOURA, LEANDRO PEREIRA; ROPELLE, EDUARDO ROCHETE; CINTRA, DENNYS ESPER; et al. Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women. Amino Acids, v. 53, n. 9, JUL 2021. (17/08036-5, 17/10080-2)

DE CARVALHO, FLAVIA GIOLO; CUNHA BRANDAO, CAMILA FERNANDA; BATITUCCI, GABRIELA; SOUZA, ANDERSON DE OLIVEIRA; FERRARI, GUSTAVO DUARTE; ALBERICI, LUCIANE CARLA; MUNOZ, VITOR ROSETTO; PAULI, JOSE RODRIGO; DE MOURA, LEANDRO PEREIRA; ROPELLE, EDUARDO ROCHETE; et al. Taurine supplementation associated with exercise increases mitochondrial activity and fatty acid oxidation gene expression in the subcutaneous white adipose tissue of obese women. Clinical Nutrition, v. 40, n. 4, p. 2180-2187, APR 2021. (17/08036-5, 17/10080-2)