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Effects of taurine supplementation associated or not to exercise on mitochondrial function, energy expenditure and inflammatory profile in obese women

Grant number: 17/08036-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Ellen Cristini de Freitas
Grantee:Flávia Giolo de Carvalho
Home Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):18/17711-0 - Epigenomic regulation of fat patterning in women (apple vs. pear), BE.EP.PD

Abstract

INTRODUCTION: Taurine supplementation researches has increased due to its antioxidant and anti-inflammatory actions, and its ability to modulate lipid metabolism by stimulating the expression of proteins that regulates mitochondrial biogenesis and increases respiratory function (PGC-1± and PPAR). Since obesity can induce metabolic disorders including abnormal production of adipokines and activation of pro-inflammatory signaling pathways also mitochondrial metabolism dysfunction in the adipose tissue, the use of taurine would be a new strategy for obesity prevention and treatment. Moreover, the association of taurine and exercise could improve exercise effects, promote higher energy expenditure and increase mitochondrial respiration, consequently resulting in weight loss. METHODS: 40 obese women will be recruited for this study. The study will consist of 8-week supplementation period with taurine (3 grams) or placebo associated or not with exercise. In order to check the effects of the intervention, abdominal tissue biopsy will be performed for histological adipose tissue analysis, evaluation of mitochondrial function and quantification of uncoupling proteins (UPCs 1 and 2), PGC 1 ± and PPAR; blood collection will be done for quantification of taurine and of inflammatory markers (IL-10, IL-6, IL-1, TNF-± and CRP) before and after the supplementation period. And body composition will be evaluated by deuterium oxide method. OUTCOMES: It is expected that taurine supplementation associated with exercise will reestablish mitochondrial function of the adipose tissue, increase energy expenditure, decrease weight and body fat mass, and benefit the inflammatory profile of obese women. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CARVALHO, MILENA BARBON; CUNHA BRANDAO, CAMILA FERNANDA; FASSINI, PRISCILA GIACOMO; BIANCO, THIAGO MANTELLO; BATITUCCI, GABRIELA; MARTINEZ GALAN, BRYAN STEVE; DE CARVALHO, FLAVIA GIOLO; VIEIRA, TALES SAMBRANO; FERRIOLLI, EDUARDO; MARCHINI, JULIO SERGIO; RAMOS DA SILVA, ADELINO SANCHEZ; DE FREITAS, ELLEN CRISTINI. Taurine Supplementation Increases Post-Exercise Lipid Oxidation at Moderate Intensity in Fasted Healthy Males. NUTRIENTS, v. 12, n. 5 MAY 2020. Web of Science Citations: 0.
BATITUCCI, GABRIELA; CUNHA BRANDAO, CAMILA FERNANDA; DE CARVALHO, FLAVIA GIOLO; MARCHINI, JULIO SERGIO; PFRIMER, KARMA; FERRIOLI, EDUARDO; CUNHA, FERNANDO QUEIROZ; PAPOTI, MARCELO; BARROS MORHY TERRAZAS, SARA IVONE; JUNQUEIRA-FRANCO, MARCIA VARELLA MORANDI; RAMOS DA SILVA, ADELINO SANCHEZ; DE FREITASA, ELLEN CRISTINI. Taurine supplementation increases irisin levels after high intensity physical training in obese women. CYTOKINE, v. 123, NOV 2019. Web of Science Citations: 0.
DE CARVALHO, FLAVIA G.; JUSTICE, JAMIE N.; DE FREITAS, ELLEN C.; KERSHAW, ERIN E.; SPARKS, LAUREN M. Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality. NUTRIENTS, v. 11, n. 11 NOV 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.