| Texto completo | |
| Autor(es): Mostrar menos - |
Jenner, Raimundo
;
Fatureto-Borges, Fernanda
;
Costa-Hong, Valeria
;
Lopes, Heno F.
;
Teixeira, Sandra H.
;
Marum, Elias
;
Giorgi, Dante A. M.
;
Consolim-Colombo, Fernanda M.
;
Bortolotto, Luiz A.
;
Lorenzi-Filho, Geraldo
;
Krieger, Eduardo M.
;
Drager, Luciano F.
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF CLINICAL HYPERTENSION; v. 19, n. 9, p. 910-918, SEP 2017. |
| Citações Web of Science: | 11 |
| Resumo | |
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1 +/- 2.2 vs 12.7 +/- 2.4m/s, P=.04; women: 11.8 +/- 2.4 vs 13.2 +/- 2.2m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex. (AU) | |
| Processo FAPESP: | 12/02953-2 - Impacto da apneia obstrutiva do sono e da duração do sono sobre a progressão das doenças cardiovasculares |
| Beneficiário: | Luciano Ferreira Drager |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |