Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension

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Jenner, Raimundo ; Fatureto-Borges, Fernanda ; Costa-Hong, Valeria ; Lopes, Heno F. ; Teixeira, Sandra H. ; Marum, Elias ; Giorgi, Dante A. M. ; Consolim-Colombo, Fernanda M. ; Bortolotto, Luiz A. ; Lorenzi-Filho, Geraldo ; Krieger, Eduardo M. ; Drager, Luciano F.

• Document type: Journal article
• Source: JOURNAL OF CLINICAL HYPERTENSION; v. 19, n. 9, p. 910-918, SEP 2017.
• Web of Science Citations: 11

Abstract

Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1 +/- 2.2 vs 12.7 +/- 2.4m/s, P=.04; women: 11.8 +/- 2.4 vs 13.2 +/- 2.2m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex. (AU)

• FAPESP's process: 12/02953-2 - Impact of obstructive sleep apnea and sleep duration on the progression of cardiovascular diseases
• Grantee: Luciano Ferreira Drager
• Support Opportunities: Research Grants - Young Investigators Grants