Impact of sleep disorders on hypertension: a multifaceted approach

• Grant number: 19/23496-8
• Support type: Research Projects - Thematic Grants
• Duration: July 01, 2020 - June 30, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Luciano Ferreira Drager
• Grantee: Luciano Ferreira Drager
• Home Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Assoc. researchers: Andrea Pio de Abreu ; Geraldo Lorenzi Filho ; Gerhardus Hermanus Maria Schoorlemmer ; Giovanio Vieira da Silva ; Isabela Judith Martins Bensenor ; Madson Queiroz Almeida ; Paulo Andrade Lotufo ; Ronaldo Batista dos Santos ; Silvana de Barros

Abstract

Sleep Disorders are increasingly common clinical conditions in our Society. Among these, we highlighted two of them: Obstructive Sleep Apnea (OSA) and short sleep duration (SSD). Previous studies suggested a positive association of sleep disorders with several cardiovascular diseases, including hypertension (HTN). Despite the advances in the area, several important issues remain poorly explored: 1) in isolation, both OSA and SSD are associated with HTN. However, studies that evaluated OSA did not consider the presence of CDS and vice versa. In addition, most of the studies evaluated sleep duration subjectively; 2) the role of OSA in target organ damage (TOD) in HTN is unclear; 3) the prognostic impact of OSA on resistant hypertension has not been studied; 4) the interaction of OSA with other causes of secondary HTN was little explored; 5) according to a recent statement from the American Heart Association, the effects of CPAP on blood pressure (BP) is still not well established, including in hypertensive patients with comorbidities, such as patients with chronic kidney disease; 6) the effect of CPAP on BP reduction is variable and the development of biomarkers predicting BP response and increased cardiovascular risk is highly desirable. Using a multidisciplinary and international collaboration approach, this Thematic Project aims to answer questions with clear clinical relevance on the impact of sleep disorders on HTN and TOD, the effect of OSA treatment on BP and TOD, the evaluation of potential mechanisms involved and the potential creation of biomarkers that predict risk and response to OSA treatment. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIATTI, SORAYA; SANTOS, RONALDO B.; AIELO, ALINE N.; SILVA, WAGNER A.; PARISE, BARBARA K.; SOUZA, SILVANA P.; PIO-ABREU, ANDREA; BORTOLOTTO, LUIZ A.; LOTUFO, PAULO A.; BENSENOR, ISABELA M.; DRAGER, LUCIANO F. Association of Sodium with Obstructive Sleep Apnea The ELSA-Brasil Study. ANNALS OF THE AMERICAN THORACIC SOCIETY, v. 18, n. 3, p. 502-510, MAR 2021. Web of Science Citations: 1.