Bariatric Surgery and Precision Nutrition

Autor(es)

Nicoletti, Carolina F. ^[1] ; Cortes-Oliveira, Cristiana ^[1] ; Pinhel, Marcela A. S. ^{[1, 2]} ; Nonino, Carla B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Sao Paulo - Brazil

^[2] Sao Jose do Rio Preto Med Sch, Dept Mol Biol, BR-15090000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 9, n. 9 SEP 2017.
• Citações Web of Science: 10

Resumo

This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of nutritional genomics: nutrigenetics, nutrigenomics, and epigenetics. We present studies that show the effect of each patient's genetic and epigenetic variables on the response to surgical weight loss treatment. We include investigations that demonstrate the association of single nucleotide polymorphisms with obesity phenotypes and their influence on weight loss after bariatric surgery. We also present reports on how significant weight loss induced by bariatric surgery impacts telomere length, and we discuss studies on the existence of an epigenetic signature associated with surgery outcomes and specific gene methylation profile, which may help to predict weight loss after a surgical procedure. Finally, we show articles which evidence that bariatric surgery may affect expression of numerous genes involved in different metabolic pathways and consequently induce functional and taxonomic changes in gut microbial communities. The role nutritional genomics plays in responses to weight loss after bariatric surgery is evident. Better understanding of the molecular pathways involved in this process is necessary for successful weight management and maintenance. (AU)

• Processo FAPESP: 16/05638-1 - Padrão de metilação global do DNA antes e após tratamentos para perda de peso
• Beneficiário: Carla Barbosa Nonino
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/12819-4 - Alterações genéticas, clínicas, bioquímicas e de variabilidade cardíaca na obesidade grau III pré e pós-cirurgia bariátrica
• Beneficiário: Marcela Augusta de Souza Pinhel
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/18669-0 - Avaliação do padrão de Metilação do DNA antes e após derivação gástrica em Y de Roux
• Beneficiário: Carolina Nicoletti Ferreira Fino
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado