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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

HPV-11 variability, persistence and progression to genital warts in men: the HIM study

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Autor(es):
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Flores-Diaz, Ema [1] ; Sereday, Karen A. [2] ; Ferreira, Silvaneide [1] ; Sirak, Bradley [2] ; Sobrinho, Joao Simao [1] ; Baggio, Maria Luiza [1] ; Galan, Lenice [3] ; Silva, Roberto C. [4] ; Lazcano-Ponce, Eduardo [5] ; Giuliano, Anna R. [2] ; Villa, Luisa L. [6, 1] ; Sichero, Laura [1] ; Grp, HIM Study
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Mol Biol La, Ctr Translat Res Oncol, Hosp Clin, Sao Paulo - Brazil
[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL - USA
[3] Ludwig Inst Canc Res, Sao Paulo Branch, Sao Paulo - Brazil
[4] Ctr Referencia & Treinamento DST Aids, Sao Paulo - Brazil
[5] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos - Mexico
[6] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF GENERAL VIROLOGY; v. 98, n. 9, p. 2339-2342, SEP 2017.
Citações Web of Science: 7
Resumo

HPV-11 and HPV-6 are the etiological agents of about 90% of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development. (AU)

Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
Beneficiário:Luisa Lina Villa
Modalidade de apoio: Auxílio à Pesquisa - Temático