HPV-11 variability, persistence and progression to genital warts in men: the HIM study

Author(s):Show less -

Flores-Diaz, Ema ^[1] ; Sereday, Karen A. ^[2] ; Ferreira, Silvaneide ^[1] ; Sirak, Bradley ^[2] ; Sobrinho, Joao Simao ^[1] ; Baggio, Maria Luiza ^[1] ; Galan, Lenice ^[3] ; Silva, Roberto C. ^[4] ; Lazcano-Ponce, Eduardo ^[5] ; Giuliano, Anna R. ^[2] ; Villa, Luisa L. ^{[6, 1]} ; Sichero, Laura ^[1] ; Grp, HIM Study

Affiliation

^[1] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Mol Biol La, Ctr Translat Res Oncol, Hosp Clin, Sao Paulo - Brazil

^[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL - USA

^[3] Ludwig Inst Canc Res, Sao Paulo Branch, Sao Paulo - Brazil

^[4] Ctr Referencia & Treinamento DST Aids, Sao Paulo - Brazil

^[5] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos - Mexico

^[6] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF GENERAL VIROLOGY; v. 98, n. 9, p. 2339-2342, SEP 2017.
• Web of Science Citations: 7

Abstract

HPV-11 and HPV-6 are the etiological agents of about 90% of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development. (AU)

• FAPESP's process: 08/57889-1 - Institute of Science and Technology to study Diseases Associated with Papillomavirus
• Grantee: Luisa Lina Villa
• Support Opportunities: Research Projects - Thematic Grants