Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy

Autor(es)

Bagshaw, Andrew P. ^{[1, 2]} ; Hale, Joanne R. ^{[1, 2, 3]} ; Campos, Brunno M. ^[4] ; Rollings, David T. ^{[1, 2, 5]} ; Wilson, Rebecca S. ^{[1, 2]} ; Alvim, Marina K. M. ^[4] ; Coan, Ana Carolina ^[4] ; Cendes, Fernando ^[4]

Afiliação do(s) autor(es)

^[1] Univ Birmingham, Ctr Human Brain Hlth, Birmingham, W Midlands - England

^[2] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands - England

^[3] Univ Hosp Coventry & Warwickshire, Clin Phys & Bioengn, Coventry, W Midlands - England

^[4] Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Campinas, SP - Brazil

^[5] Queen Elizabeth Hosp Birmingham, Dept Neurosci, Birmingham, W Midlands - England

• Tipo de documento: Artigo Científico
• Fonte: NEUROIMAGE-CLINICAL; v. 16, p. 52-57, 2017.
• Citações Web of Science: 5

Resumo

The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three types of thalamic FC: thalamocortical, inter-hemispheric thalamic, and intra-hemispheric thalamic. Patients and controls differed in all three measures, and during wakefulness and sleep, indicating disorder-dependent and state-dependent modification of thalamic FC. Inter-hemispheric thalamic FC differed between patients and controls in somatosensory regions during wakefulness, and occipital regions during sleep. Intra-hemispheric thalamic FC was significantly higher in patients than controls following sleep onset, and disorder-dependent alterations to FC were seen in several thalamic regions always involving somatomotor and occipital regions. As interactions between thalamic sub-regions are indirect and mediated by the inhibitory thalamic reticular nucleus (TRN), the results suggest abnormal TRN function in patients with IGE, with a regional distribution which could suggest a link with the thalamocortical networks involved in the generation of alpha rhythms. Intra-thalamic FC could be a more widely applicable marker beyond patients with IGE. (AU)

• Processo FAPESP: 12/50894-5 - Magnetic resonance imaging and in vivo spectroscopy methods for neuroimaging and multimodal neurosciences studies
• Beneficiário: Alberto Tannús
• Modalidade de apoio: Auxílio à Pesquisa - Regular