The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis

Autor(es)

Issaho, Dayane Cristine ^{[1, 2]} ; de Souza Carvalho, Fabio Ramos ^[1] ; Uyeno Tabuse, Marcia Keiko ^[1] ; Carrijo-Carvalho, Linda Christian ^[1] ; de Freitas, Denise ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Ophthalmol & Visual Sci, Sao Paulo - Brazil

^[2] Hosp Olhos Parana, Coronel Dulcidio, 199, 1 Andar, BR-80420170 Curitiba, PR - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 58, n. 12, p. 5468-5476, OCT 2017.
• Citações Web of Science: 4

Resumo

PURPOSE. The purpose of this review was to examine the efficacy of botulinum toxin in the treatment of infantile esotropia and to evaluate the average response of BT and its complication rates. METHODS. A research was performed in the Latin American and Caribbean Literature on Health Sciences (LILACS), MEDLINE, and Cochrane Central Register of Controlled Trial (CENTRAL). The database was searched between December 28, 2016 and January 30, 2017. The selection was restricted to articles published in English, Spanish, or Portuguese. There were no date restrictions in the search. RESUITS. Nine studies were eligible for inclusion. The grouped success rate of BT treatment in infantile esotropia was 76% (95% confidence interval {[}CI]: 61%-89%). For the success rate, 1 2 of 94.25% was observed, indicating a high heterogeneity (P < 0.001). The complication rates were also analyzed. The grouped consecutive exotropia (X'F) rate was 1% (95% CI: 0%-2%). The grouped ptosis rate was 27% (95% CI: 21%-33%). The grouped vertical deviation rate was 12% (95% CI: 4%-22%). The mean change of the deviation after BT injection was -30.7 (95% CI: -37.7, -23.8), demonstrating a significant improvement in alignment. CONCLUSIONS. Botulinum toxin injection into medial recti muscles reveals to be a safe procedure and a valuable alternative to strabismus surgery in congenital esotropia, especially in moderate deviations. (AU)

• Processo FAPESP: 12/15603-0 - Toxinas de Acanthamoeba spp como fatores de virulência em infecções da superfície ocular
• Beneficiário: Fábio Ramos de Souza Carvalho
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 11/51626-1 - Toxinas de Acanthamoeba spp. como fatores de virulência em infecções da superfície ocular
• Beneficiário: Fábio Ramos de Souza Carvalho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores