Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis

Full text
Author(s):
Issaho, Dayane Cristine [1, 2] ; de Souza Carvalho, Fabio Ramos [1] ; Uyeno Tabuse, Marcia Keiko [1] ; Carrijo-Carvalho, Linda Christian [1] ; de Freitas, Denise [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Ophthalmol & Visual Sci, Sao Paulo - Brazil
[2] Hosp Olhos Parana, Coronel Dulcidio, 199, 1 Andar, BR-80420170 Curitiba, PR - Brazil
Total Affiliations: 2
Document type: Review article
Source: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE; v. 58, n. 12, p. 5468-5476, OCT 2017.
Web of Science Citations: 4
Abstract

PURPOSE. The purpose of this review was to examine the efficacy of botulinum toxin in the treatment of infantile esotropia and to evaluate the average response of BT and its complication rates. METHODS. A research was performed in the Latin American and Caribbean Literature on Health Sciences (LILACS), MEDLINE, and Cochrane Central Register of Controlled Trial (CENTRAL). The database was searched between December 28, 2016 and January 30, 2017. The selection was restricted to articles published in English, Spanish, or Portuguese. There were no date restrictions in the search. RESUITS. Nine studies were eligible for inclusion. The grouped success rate of BT treatment in infantile esotropia was 76% (95% confidence interval {[}CI]: 61%-89%). For the success rate, 1 2 of 94.25% was observed, indicating a high heterogeneity (P < 0.001). The complication rates were also analyzed. The grouped consecutive exotropia (X'F) rate was 1% (95% CI: 0%-2%). The grouped ptosis rate was 27% (95% CI: 21%-33%). The grouped vertical deviation rate was 12% (95% CI: 4%-22%). The mean change of the deviation after BT injection was -30.7 (95% CI: -37.7, -23.8), demonstrating a significant improvement in alignment. CONCLUSIONS. Botulinum toxin injection into medial recti muscles reveals to be a safe procedure and a valuable alternative to strabismus surgery in congenital esotropia, especially in moderate deviations. (AU)

FAPESP's process: 12/15603-0 - Acanthamoeba spp toxins as virulence factors in infections of the ocular surface
Grantee:Fábio Ramos de Souza Carvalho
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 11/51626-1 - Acanthamoeba spp. toxins as virulence factors in infections of the ocular surface
Grantee:Fábio Ramos de Souza Carvalho
Support Opportunities: Research Grants - Young Investigators Grants