Energy Metabolism of Bone

Autor(es)

Motyl, Katherine J. ^[1] ; Guntur, Anyonya R. ^[2] ; Carvalho, Adriana Lelis ^[3] ; Rosen, Clifford J. ^[2]

Afiliação do(s) autor(es)

^[1] Maine Med Ctr Res Inst, Ctr Mol Med, 81 Res Dr, Scarborough, ME 04074 - USA

^[2] Maine Med Ctr Res Inst, Ctr Clin & Translat Res, Scarborough, ME - USA

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TOXICOLOGIC PATHOLOGY; v. 45, n. 7, p. 887-893, OCT 2017.
• Citações Web of Science: 4

Resumo

Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is better suited to withstand loading demands. Osteoclasts, osteoblasts, and osteocytes are the primary cells responsible for bone remodeling, although bone marrow adipocytes and other cells may also play an indirect role. There is a renewed interest in bone cell energetics because of the potential for these processes to be targeted for osteoporosis therapies. In contrast, due to the intimate link between bone and energy homeostasis, pharmaceuticals that treat metabolic disease or have metabolic side effects often have deleterious bone consequences. In this brief review, we will introduce osteoporosis, discuss how bone cells utilize energy to function, evidence for bone regulating whole body energy homeostasis, and some of the unanswered questions and opportunities for further research in the field. (AU)

• Processo FAPESP: 14/14505-0 - Efeitos do balanço energético sobre a massa óssea e a adiposidade da medula óssea no diabetes melito do tipo 1
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/09853-6 - Relação da Adiposidade Visceral, Hepática e Óssea com a Densidade Mineral Óssea e Ocorrência de Fratura no Diabetes Melito tipo 1.
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado