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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Energy Metabolism of Bone

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Author(s):
Motyl, Katherine J. [1] ; Guntur, Anyonya R. [2] ; Carvalho, Adriana Lelis [3] ; Rosen, Clifford J. [2]
Total Authors: 4
Affiliation:
[1] Maine Med Ctr Res Inst, Ctr Mol Med, 81 Res Dr, Scarborough, ME 04074 - USA
[2] Maine Med Ctr Res Inst, Ctr Clin & Translat Res, Scarborough, ME - USA
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: TOXICOLOGIC PATHOLOGY; v. 45, n. 7, p. 887-893, OCT 2017.
Web of Science Citations: 4
Abstract

Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is better suited to withstand loading demands. Osteoclasts, osteoblasts, and osteocytes are the primary cells responsible for bone remodeling, although bone marrow adipocytes and other cells may also play an indirect role. There is a renewed interest in bone cell energetics because of the potential for these processes to be targeted for osteoporosis therapies. In contrast, due to the intimate link between bone and energy homeostasis, pharmaceuticals that treat metabolic disease or have metabolic side effects often have deleterious bone consequences. In this brief review, we will introduce osteoporosis, discuss how bone cells utilize energy to function, evidence for bone regulating whole body energy homeostasis, and some of the unanswered questions and opportunities for further research in the field. (AU)

FAPESP's process: 14/14505-0 - Effect of energy balance on bone mass and marrow fat in type 1 diabetes mellitus
Grantee:Adriana Lelis Carvalho
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 13/09853-6 - Relationship between visceral, hepatic and bone adiposity with bone mineral density and fracture occurrence in type 1 diabetes mellitus.
Grantee:Adriana Lelis Carvalho
Support Opportunities: Scholarships in Brazil - Doctorate