Insights into regulation of the miR-17-92 cluster of miRNAs in cancer

Autor(es)

Fuziwara, Cesar Seigi ^[1] ; Kimura, Edna Teruko ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 1524, Room 414, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN MEDICINE; v. 2, 2015.
• Citações Web of Science: 49

Resumo

Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGF beta signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the clusters oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. (AU)

• Processo FAPESP: 13/11019-4 - Papel da nova família de proteínas tumor-específicas FAM83 no câncer de tiróide
• Beneficiário: Edna Teruko Kimura
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50521-0 - Regulação transcricional do microRNA miR-17-92 no câncer de tiroide agressivo
• Beneficiário: Cesar Seigi Fuziwara
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado