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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Insights into regulation of the miR-17-92 cluster of miRNAs in cancer

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Autor(es):
Fuziwara, Cesar Seigi [1] ; Kimura, Edna Teruko [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 1524, Room 414, BR-05508000 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN MEDICINE; v. 2, 2015.
Citações Web of Science: 51
Resumo

Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGF beta signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the clusters oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. (AU)

Processo FAPESP: 14/50521-0 - Regulação transcricional do microRNA miR-17-92 no câncer de tiroide agressivo
Beneficiário:Cesar Seigi Fuziwara
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/11019-4 - Papel da nova família de proteínas tumor-específicas FAM83 no câncer de tiróide
Beneficiário:Edna Teruko Kimura
Linha de fomento: Auxílio à Pesquisa - Regular