| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 1524, Room 414, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Review article |
| Source: | FRONTIERS IN MEDICINE; v. 2, 2015. |
| Web of Science Citations: | 49 |
| Abstract | |
Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGF beta signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the clusters oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. (AU) | |
| FAPESP's process: | 13/11019-4 - Role of the new family of tumor-specific proteins FAM83 in thyroid cancer |
| Grantee: | Edna Teruko Kimura |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50521-0 - Transcriptional regulation of miR-17-92 microRNA in aggressive thyroid cancer |
| Grantee: | Cesar Seigi Fuziwara |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |