Strategies to Inactivate the Endogenous Dentin Proteases to Promote Resin-Dentin Bond Longevity in Adhesive Dentistry: A Critical Review

Autor(es)

Palma-Dibb, Regina Guenka ^[1] ; Rego Roselino, Lourenco de Moraes ^[1] ; Neto, Pedro Turrini ^[1] ; Faraoni, Juliana Jendiroba ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Restorat Dent, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: REVIEWS OF ADHESION AND ADHESIVES; v. 5, n. 4, p. 391-413, DEC 2017.
• Citações Web of Science: 0

Resumo

The longevity of a composite resin restoration is constantly being sought in the field of dentistry. The matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs) in the dentin matrix when activated participate in the degradation of collagen fibrils and extracellular components. The preservation of the structural integrity of collagen and the matrix maintains the mechanical properties, chemical stability and resistance to degradation of resin-dentin bonded interface, contributing to restoration durability. Thus, it is of fundamental importance to employ methods and / or agents that promote the inactivation of MMPs and CCs to improve the chemical stability of the adhesive interface. So, several crosslinking agents have been studied (natural and synthetic), however it is observed that chitosan and proanthocyanidin show reliable results and both promote protease inactivation and provide better collagen web resistance, and thus increase the longevity of the restoration procedure. (AU)

• Processo FAPESP: 15/26200-1 - Efeito da dentina tratada com epigalocatequina-3-galato e quitosana: propriedades físico-químicas
• Beneficiário: Lourenço de Moraes Rego Roselino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/23193-7 - Efetividade de tratamentos preventivos na erosão de dentina: estudo in vitro e in situ
• Beneficiário: Juliana Jendiroba Faraoni
• Modalidade de apoio: Auxílio à Pesquisa - Regular