Strategies to Inactivate the Endogenous Dentin Proteases to Promote Resin-Dentin Bond Longevity in Adhesive Dentistry: A Critical Review

Author(s)

Palma-Dibb, Regina Guenka ^[1] ; Rego Roselino, Lourenco de Moraes ^[1] ; Neto, Pedro Turrini ^[1] ; Faraoni, Juliana Jendiroba ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Restorat Dent, Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: REVIEWS OF ADHESION AND ADHESIVES; v. 5, n. 4, p. 391-413, DEC 2017.
• Web of Science Citations: 0

Abstract

The longevity of a composite resin restoration is constantly being sought in the field of dentistry. The matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs) in the dentin matrix when activated participate in the degradation of collagen fibrils and extracellular components. The preservation of the structural integrity of collagen and the matrix maintains the mechanical properties, chemical stability and resistance to degradation of resin-dentin bonded interface, contributing to restoration durability. Thus, it is of fundamental importance to employ methods and / or agents that promote the inactivation of MMPs and CCs to improve the chemical stability of the adhesive interface. So, several crosslinking agents have been studied (natural and synthetic), however it is observed that chitosan and proanthocyanidin show reliable results and both promote protease inactivation and provide better collagen web resistance, and thus increase the longevity of the restoration procedure. (AU)

• FAPESP's process: 15/26200-1 - EFFECT OF DENTIN TREATED WITH EPIGALLOCATECHIN-3-GALLATE AND CHITOSAN: PHYSICOCHEMICAL PROPERTIES
• Grantee: Lourenço de Moraes Rego Roselino
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/23193-7 - Effectiveness of preventive treatments in the erosion of dentin: in vitro and in situ study
• Grantee: Juliana Jendiroba Faraoni
• Support Opportunities: Regular Research Grants