Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases

Autor(es)

Melo, Daniel Hardy ^[1] ; Martins Mamede, Rui Celso ^[2] ; Neder, Luciano ^[3] ; Silva, Jr., Wilson Araujo ^[4] ; Barros-Filho, Mateus Camargo ^[5] ; Kowalski, Luiz Paulo ^[5] ; Lopes Pinto, Clovis Antonio ^[6] ; Zago, Marco Antonio ^[7] ; Alves Figueiredo, David Livingstone ^[8] ; Jungbluth, Achim A. ^[9]

Afiliação do(s) autor(es)

^[1] Univ Fed Ceara, Sch Med, 100 Comandante Maurocelio Rocha Pontes Ave, BR-62042280 Sobral - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Clin Pathol, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil

^[5] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP - Brazil

^[6] AC Camargo Canc Ctr, Dept Anat Pathol, BR-01509010 Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil

^[8] Midwestern State Univ, UNICTR, Dept Pharm, BR-85040080 Guarapuava, PR - Brazil

^[9] Mem Sloan Kettering Canc Ctr, Div Pathol Diagnost Serv, Cytol, 1275 York Ave, New York, NY 10021 - USA

• Tipo de documento: Artigo Científico
• Fonte: Oncology Letters; v. 14, n. 6, p. 6485-6496, DEC 2017.
• Citações Web of Science: 1

Resumo

Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry. None of the CT antigens were expressed in the normal thyroid or goiter. In papillary and follicular carcinoma, MAGE-A was present in 8.1% of cases, GAGE in 10.8% and CT/7MAGE-C1 and CTAG1B in 2.7% each. In medullary carcinoma, CT antigen expression was as follows: MAGE-A in 42.9% of patients; MAGE-C1/CT7 in 46.5%; GAGE in 92.9%; and CTAG1B in 3.6%. A statistically significant association was observed between the expression of G MAGE-C1/CT7 and patient gender as well as patient clinical stage (P=0.029 and 0.031, respectively). (AU)

• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 12/00588-5 - Identificação e caracterização de novos circuitos gênicos relacionados às células tronco tumorais
• Beneficiário: Cleidson de Pádua Alves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado