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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases

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Author(s):
Melo, Daniel Hardy [1] ; Martins Mamede, Rui Celso [2] ; Neder, Luciano [3] ; Silva, Jr., Wilson Araujo [4] ; Barros-Filho, Mateus Camargo [5] ; Kowalski, Luiz Paulo [5] ; Lopes Pinto, Clovis Antonio [6] ; Zago, Marco Antonio [7] ; Alves Figueiredo, David Livingstone [8] ; Jungbluth, Achim A. [9]
Total Authors: 10
Affiliation:
[1] Univ Fed Ceara, Sch Med, 100 Comandante Maurocelio Rocha Pontes Ave, BR-62042280 Sobral - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Clin Pathol, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Ctr Cell Based Therapy, CEPID, FAPESP, BR-14049900 Ribeirao Preto, SP - Brazil
[5] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP - Brazil
[6] AC Camargo Canc Ctr, Dept Anat Pathol, BR-01509010 Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[8] Midwestern State Univ, UNICTR, Dept Pharm, BR-85040080 Guarapuava, PR - Brazil
[9] Mem Sloan Kettering Canc Ctr, Div Pathol Diagnost Serv, Cytol, 1275 York Ave, New York, NY 10021 - USA
Total Affiliations: 9
Document type: Journal article
Source: Oncology Letters; v. 14, n. 6, p. 6485-6496, DEC 2017.
Web of Science Citations: 0
Abstract

Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry. None of the CT antigens were expressed in the normal thyroid or goiter. In papillary and follicular carcinoma, MAGE-A was present in 8.1% of cases, GAGE in 10.8% and CT/7MAGE-C1 and CTAG1B in 2.7% each. In medullary carcinoma, CT antigen expression was as follows: MAGE-A in 42.9% of patients; MAGE-C1/CT7 in 46.5%; GAGE in 92.9%; and CTAG1B in 3.6%. A statistically significant association was observed between the expression of G MAGE-C1/CT7 and patient gender as well as patient clinical stage (P=0.029 and 0.031, respectively). (AU)

FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC